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Pharmacogenomics 

• The Human Pregnane X Receptor: Genomic Structure and Identification and Functional Characterization of Natural Allelic Variants (2001) |PubMed|PDF|
• Sequence Diversity in CYP3A Promoters and Characterization of the Genetic Basis   of Polymorphic CP3A5 Expression (2001) |PubMed|PDF|
• PharmGKB Update: II. CYP3A5, Cytochrome P450, Family 3, Subfamily a, Polypeptide 5 (2004) |PubMed|PDF|

Also of note: my interview with the Personalized Medicine Coalition

Various Genotypes of the Pregnane X Receptor Gene

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Cytogenetic location on chromosome 3q13-21 of the Pregnane X Receptor gene, a key regulator of drug metabolism.

© Dr. Mark S. Boguski, All rights reserved